The single-lane Cleveland Redland Bay Road was expected to be closed into the night as the scene was cleared and forensic crash unit investigations took place.
On social media, police initially said delays of up to three hours could be expected.
It comes just months after Redland Bay woman Mersina Axiom died close to the intersection after a multi-vehicle crash in February.
Emergency services, including critical care paramedics, were also called to a single-vehicle rollover in the Somerset region on Tuesday afternoon.
A rescue helicopter was also tasked to the scene on Neurum Road at Glenfern, near Kilcoy, with one patient believed to be trapped inside.